Cis-4,5-didehydro-16-phenoxy-PGA.sub.1 compounds

Magerlein, Barney J.;

The disclosure includes novel compounds which differ from the known prostaglandins PGF.sub.2.alpha., PGF.sub.2.beta., PGE.sub.2, PGA.sub.2, and PGB.sub.2 in that the carbon-carbon double bond in the carboxyl-terminated chain of the novel compounds is in the 4,5-position rather than in the 5,6-position, and in that there is a phenoxy or substituted phenoxy group in the other chain of the novel compounds. These novel compounds are useful for a variety of pharmacological purposes, including abortion, labor induction, and reduction of gastric secretion.






  • .alpha.-ACETYLENIC DERIVATIVES OF AMINES .omega.-Aryl-13,14-didehydro-inter-oxa-PGA compounds
  • 1,2-Diphenyl-3,5-ditrifluoroacetyloxy-4-butyl-5-hydroxy-3-pyrazoline 1,3-Dicarbonyl compounds
  • 1-Alkyl-4-isopropylbenzene desorbents for para-xylene 1-Nitro-9-alkylaminoalkylaminoacridines and salts thereof
  • 1-Substituted-3-aminoethoxypyrrolidines and use thereof 19-Nor-D-homopregnanes
  • 2-Aryl-2-halomethyl-4-alkenyl-1,3-dioxolanes 2-Decarboxy-2-hydroxymethyl)-16-fluoro-PGE.sub.2 compounds
  • 3-Aryloxy-1-(2- or 4-iminodihydro-1-pyridyl)-2-propanol antiarrhythmic compounds 3-Cyano-2-pyridinyloxymethyl-oxazolidine derivatives
  • Acoustic driving of rotor Aerosol propellant for personal products
  • Aircraft proximity warning indicator Alarm system
  • Alkoxypyridyl substituted alkanes All-metal hammer handle adapter construction
  • Aminated starch derivatives Amino-spiro[oxa(or thia)cycloalkane-penam]-carboxylic acid derivatives
  • Ammonium nitrate neutralization Analog computer
  • Anesthetic lozenges Anionic silicone defoamer
  • Anthelmintic 5(6)-benzene ring substituted benzimidazole-2-carbamates Antitack agent
  • Apparatus for making slide fasteners Apparatus for speech pattern derivation
  • Apparatus for vehicle position indication Aqueous vehicles
  • Aralkyl carboxylic acid compounds Aromatics from synthesis gas
  • Artificial intraocular lens Assembly method for fire hydrants
  • Audible alarm unit Audio frequency amplifier
  • Automatic automobile light control system Bathroom cabinet
  • Battery charging apparatus Benzo-[c]-cinnolinium dyestuffs
  • Boresight method and apparatus Bowling lane surface
  • Calculator program security system Carburetor
  • Carburetor Carpet cleaning device
  • Carrier current communications system Catalytic preparation of soluble poly(dichlorophosphazenes)
  • CCD Input circuits Cephalosporin type antibacterials
  • Chroma generation system CMOS polarity reversal circuit
  • Coloring agents for edible materials Colorless allyl diglycol carbonate articles
  • Consolidation of aggregate material Continuous polymerization of 2-pyrrolidone
  • Control for electrical positioning drives Control lever actuated switch
  • Copy paper test apparatus Cutaneous communication device
  • Cyclic amino containing benzisothiazoles Cyclic carbonate trimer of 2,2-bis(4-hydroxyphenyl)-1,1-dichloroethylene
  • Cyclic-substituted derivatives of 1-amino-2-propanol Dehydrogenation of naphthene hydrocarbons
  • Device for multiplexing video signals Device for stopping passenger conveyor
  • Dietetic foodstuff and its production Digital data reformatter/deserializer
  • Dihydroethanoanthracene derivatives Document storage and retrieval system
  • Door hinge, particularly for refrigerators Duct junction fitting
  • Dynamic compensation for multi-loop controls Electric induction heating furnace
  • Electric shaver Electrical energy transmission network
  • Electrically heated kitchen utensil Electromagnetic information display system
  • Electronic postage scale Event monitor for court games
  • Extensible maternity slacks Fault protection circuit
  • Flash-wink generating circuit Flashlight burglar alarm apparatus
  • Flavoring with a tricyclic alcohol Flexible glycolic acid terpolymers
  • Gain control circuit Gas-type circuit-breaker
  • Gemstone cloisonne Glass-coated thick film resistor
  • Ground station data storage system Headset
  • High voltage generating device Hinge fitting
  • Humidifier Hydrogen-oxygen recombiner
  • Hyphenation controller Imaging chamber with electrode structure
  • Impedance-switching connector Indole cephalosporin derivatives
  • Information entry system Instrument for air ionization
  • Integrated read only memory Ladderless D/A converter
  • Laserbeam recording Light-responsive electric switch
  • Lightweight, disposable transportation casket Line-addressable random-access memory decoupling apparatus
  • Linear distortion measuring Liquid level indicating device
  • Logic gate circuits Logic state analyzer
  • Luminaire lowering device Manufacture of 2-amino-3-bromoanthraquinone
  • Mechanical securement of extrusions Method for preparing copolyether glycols
  • Method of removing citrus-fruit-pulp-segment membranes Methyldi(trimethylsiloxy)sylylpropylglycerol methacrylate
  • Microfilm searching reader Multi-channel generator drive system
  • Multiflash system Multifunction frequency counter
  • N-(4-substituted-3,5-dichloro-phenyl)-piperazines N-Acylaminonaphthalimides
  • Nonionic surface active anti-viral agents Nonylamines
  • Optoelectronic memory Oxazolidinones as therapeutic agents
  • Packaging material Permanent waving composition
  • Photoconductor for imaging devices Photodetector with improved signal-to-noise ratio
  • Photovoltaic-ferroelectric data recorder Plasma discharge ion source
  • Polymeric basic amides Polymorphic support systems
  • Polyvinyl quaternaries Preparation of hexahydroindazolones
  • Preparation of insoluble polyvinylpyrrolidone Printing and coating method
  • Process for forming fluorspar compacts Process for making methyl fluoride
  • Process for preparing cephalosporines Process for preparing diphenyl haloethylenes
  • Process for preparing free-flowing 2-nitro-4-acetylamino-anisole Process for purifying crude p-aminophenol
  • Process for treating cottonseed meats Producing sulphuric acid
  • Production of thermally stabilized polyester Production of unsaturated nitriles
  • Protective hairdressing cape Protein texturization
  • Pseudomonic acid amide antibacterial compounds Psychotropic 2-trifluoromethyl-10-[3-(3-hydroxy-pyrrolidino)-propyl]-phenothiazine compounds
  • Puffer-type compressed-gas circuit interrupter Pyrazolopyrimidines
  • Quinone derivatives useful as medicaments Radiography
  • Rechargeable electrochemical system Record ejecting and positioning assembly
  • Recovery of (1-S)-2-oxo-bornane-10-sulphonate Regenerator stage for CCD arrangements
  • Reinforced plastic molding material Resistance temperature sensor
  • Respiratory treatment bench and cabinet Reversible hand-held microphone
  • Rotor short-circuiting switch Schottky barrier type solid-state element
  • Secondary alcohol ethoxylate process Secondary contacts for drawout switchgear
  • Security pocket Self-lift carburetor
  • Semiconductor device package Separation technique for assays
  • Signal processing circuit Silicone containing bis-thioether aromatic amines
  • Slide switch constructions Slider for slide fasteners
  • Smoke alarm Snack food package
  • Somatostatin analogs Stabilized ethylene-carbon monoxide copolymers
  • Stationary contact combination Stereophonic television sound transmission system
  • Suction attachment for vacuum cleaner Synthesis of zeolite ZSM-5
  • Telecommunications call back system Telephone line test system
  • Television camera tube Throttle body assembly
  • Transient modulated ignition system Transparent pigmented polycarbonate container
  • Two level threshold circuit Ultrasonic wave transmitter/receiver
  • Utility knife Variable temperature recording stylus
  • Vinyl substituted cyclic polyethers Wellbore instrument hanger
  • Window shade cutter
  • present invention relates to prostaglandin analogs, for which the essential material constituting disclosure therefor is incorporated by reference here from Ser. No. 678,948.

    Timing device for fluid valve
    Failsafe logic function apparatus
    Stab-type coupling and method
    Method of treating bacterial infections
    Chucking apparatus
    Electric jewels
    Electro-acoustic transducer
    Drawer organizer
    Multipassage diffuser
    Pneumatically operated gated irrigation system
    Labelling device
    Dehydrator
    Bicycle carrying rack
    Indexable insert drill
    Doll stand
    Multi-pane window structure
    Trunk lamp assembly
    Folding closure
    Cigarette holder for ash receptacles
    Vices
    Laminated pier bumper
    Diazotype multicolor reproduction process
    Lubricant compositions
    Safety sleeve
    Scan interlock system
    Power transmission for an automobile
    Transmission line interface circuit
    Multi-beam radio frequency array antenna
    Monoazo compounds
    Polishing wheels
    Method for removing moisture particles
    Detachable helmet goggle bracket
    Rescue equipment
    Water treatment apparatus
    N-(substituted phenyl and benzyl)abietamides
    Electrical connector
    Manifold assembly fastening
    High speed lubricated bearing
    Packaged electric lamp
    Power breaker system
    Welding simulator spot designator system
    Snap action switches
    Packing for technical processes
    Display system
    Rotary cocks carrying spherical seals
    Roll leveller
    Drum stand
    Marine engine noise suppressor
    Information transmission system
    Adjustable dental chair
    2,4,5-Trichlorophenol process
    Ink jet array
    Automatic bowling lane stripper
    Pocket button attaching device
    Photographic still camera
    Fluorided composite catalyst
    Production of mushroom spawn
    Copying objective lens system
    Antimicrobial composition
    Multifunctional reference electrode
    Powdered carpet composition
    Electronic equipment enclosure connecting structure
    Derivatives of 1-(3-cyano-3,3-diphenylpropyl)-4-phenylpiperidine-4-carboxylic acid
    Monensin urethane derivatives
    Safety bindings for skis
    Cable tension roller
    Prostaglandin intermediates
    Brake assembly for a vehicle
    Fish lure desnagger
    Electronically controllable filter
    Incineration apparatus
    Electronic conveyor control apparatus
    Nozzle sealing device and assembly
    Beam bender
    Self-propelled slip form method
    Golf glove
    Dye lasers
    Method of combining synthetic yarns
    Reciprocating saw
    Expendable case ammunition
    Microwave device
    Recessed lighting fixture
    Fluid catalyst regeneration process
    Polymer emulsification process